# Creatine Sleep Deprivation Randomized Trial: What the Evidence Says
Canonical: https://www.migaku.app/guides/creatine-sleep-deprivation-randomized-trial-evidence-review
Category: evidence-review
Summary: Creatine Sleep Deprivation Randomized Trial has 2 source documents in the current Migaku evidence database. The strongest available sources in this first pass
Last reviewed: 2026-07-04
Reviewed by: Migaku Evidence Review
# Creatine Sleep Deprivation Randomized Trial: What the Evidence Says

## Quick Answer

Creatine Sleep Deprivation Randomized Trial has 2 source documents in the current Migaku evidence database. The strongest available sources in this first pass are mixed biomedical and public-health sources, so conclusions should be framed as evidence-aware guidance rather than medical advice.

## Key Takeaways

- This page is generated only from sources stored in the Migaku evidence knowledge base.
- Current evidence mix: 1 research article, 1 preclinical study.
- Claims should be interpreted with the source type, study design, population, and publication date in mind.
- This article is educational and does not replace care from a qualified clinician.

## Evidence Map

| Source | Evidence type | Level | Date | Identifier |
| --- | --- | ---: | --- | --- |
| Body-weight-specific and shared metabolomic responses to acute sleep loss in young adults | research article | 4 | 2026-06-03 | 10.1186/s12967-026-08350-4 |
| Single-Dose Creatine Reduces Sleep Deprivation-Induced Deterioration in Cognitive Performance | preclinical study | 4 | 2026-04-10 | 10.3390/nu18081192 |

## What The Sources Report

- Insufficient sleep constitutes a risk factor for adverse cardiometabolic effects, such as weight gain and obesity. [Good Linnéa (2026); evidence level 4]
- Conversely, obesity is also associated with disrupted sleep and worse sleep quality. [Good Linnéa (2026); evidence level 4]
- There is growing evidence indicating that creatine influences neuronal excitability and neurotransmission. [Gordji-Nejad Ali (2026); evidence level 4]
- In all the above cases, a cellular stress state appears to be a decisive condition for an increased uptake. [Gordji-Nejad Ali (2026); evidence level 4]

## How To Read This Evidence

Evidence level 1 generally reflects systematic reviews or meta-analyses. Level 2 includes randomized trials, guidelines, or public-health guidance. Level 3 usually reflects observational or narrative-review evidence. Level 4 is weaker or early-stage evidence. The level is a sorting aid, not a final quality grade.

## Practical Interpretation

For creatine sleep deprivation randomized trial, the current source set is useful for orientation, but it is not yet broad enough for strong claims. Use cautious language and keep conclusions close to the cited sources.

## Limits Of This First Pass

This is a small-batch MVP article. It uses the first ingested sources for this topic and should be expanded with more targeted searches, license review, and human editorial checks before being treated as a definitive review.

## References

- Good Linnéa (2026). Body-weight-specific and shared metabolomic responses to acute sleep loss in young adults. DOI: 10.1186/s12967-026-08350-4. PMCID: PMC13263921. PMID: 42231340. License: CC BY 4.0. https://pmc.ncbi.nlm.nih.gov/articles/PMC13263921/
- Gordji-Nejad Ali (2026). Single-Dose Creatine Reduces Sleep Deprivation-Induced Deterioration in Cognitive Performance. DOI: 10.3390/nu18081192. PMCID: PMC13119191. PMID: 42075005. License: CC BY 4.0. https://pmc.ncbi.nlm.nih.gov/articles/PMC13119191/

## Safety Note

Health information can change, and individual risk depends on medical history, medications, pregnancy status, age, and diagnosis. Talk with a qualified clinician before changing treatment, supplement, or medication routines.