# Creatine Mental Fatigue Meta-analysis: What the Evidence Says
Canonical: https://www.migaku.app/guides/creatine-mental-fatigue-meta-analysis-evidence-review
Category: evidence-review
Summary: Creatine Mental Fatigue Meta-analysis has 2 source documents in the current Migaku evidence database. The strongest available sources in this first pass are m
Last reviewed: 2026-08-14
Reviewed by: Migaku Evidence Review
# Creatine Mental Fatigue Meta-analysis: What the Evidence Says

## Quick Answer

Creatine Mental Fatigue Meta-analysis has 2 source documents in the current Migaku evidence database. The strongest available sources in this first pass are mixed biomedical and public-health sources, so conclusions should be framed as evidence-aware guidance rather than medical advice.

## Key Takeaways

- This page is generated only from sources stored in the Migaku evidence knowledge base.
- Current evidence mix: 2 narrative review.
- Claims should be interpreted with the source type, study design, population, and publication date in mind.
- This article is educational and does not replace care from a qualified clinician.

## Evidence Map

| Source | Evidence type | Level | Date | Identifier |
| --- | --- | ---: | --- | --- |
| Revision of Energy Metabolism Adaptations in High-Level Athletes: From Physical Performance Enhancement to Potential Therapeutic Targets in Mental Disorders | narrative review | 3 | 2026-05-11 | 10.3390/cimb48050498 |
| The emerging and evolving evidence supporting creatine as an ergogenic aid: history and applications | narrative review | 3 | 2026-03-23 | 10.1080/15502783.2026.2646627 |

## What The Sources Report

- This "lactate-pyruvate shuttle" improves energy efficiency and limits the accumulation of metabolites associated with muscle fatigue. [Larrea Ane (2026); evidence level 3]
- Improvements are also observed in respiratory chain efficiency, with increased activity of complexes I-IV and ATP synthase, reducing uncoupling and oxidative stress. [Larrea Ane (2026); evidence level 3]

## How To Read This Evidence

Evidence level 1 generally reflects systematic reviews or meta-analyses. Level 2 includes randomized trials, guidelines, or public-health guidance. Level 3 usually reflects observational or narrative-review evidence. Level 4 is weaker or early-stage evidence. The level is a sorting aid, not a final quality grade.

## Practical Interpretation

For creatine mental fatigue meta-analysis, the current source set is useful for orientation, but it is not yet broad enough for strong claims. Use cautious language and keep conclusions close to the cited sources.

## Limits Of This First Pass

This is a small-batch MVP article. It uses the first ingested sources for this topic and should be expanded with more targeted searches, license review, and human editorial checks before being treated as a definitive review.

## References

- Larrea Ane (2026). Revision of Energy Metabolism Adaptations in High-Level Athletes: From Physical Performance Enhancement to Potential Therapeutic Targets in Mental Disorders. DOI: 10.3390/cimb48050498. PMCID: PMC13204626. PMID: 42193103. License: CC BY 4.0. https://pmc.ncbi.nlm.nih.gov/articles/PMC13204626/
- Kerksick Chad (2026). The emerging and evolving evidence supporting creatine as an ergogenic aid: history and applications. DOI: 10.1080/15502783.2026.2646627. PMCID: PMC13011109. PMID: 41870601. License: CC BY 4.0. https://pmc.ncbi.nlm.nih.gov/articles/PMC13011109/

## Safety Note

Health information can change, and individual risk depends on medical history, medications, pregnancy status, age, and diagnosis. Talk with a qualified clinician before changing treatment, supplement, or medication routines.