# Creatine Memory Meta-analysis: What the Evidence Says
Canonical: https://www.migaku.app/guides/creatine-memory-meta-analysis-evidence-review
Category: evidence-review
Summary: Creatine Memory Meta-analysis has 2 source documents in the current Migaku evidence database. The strongest available sources in this first pass are systemati
Last reviewed: 2026-06-24
Reviewed by: Migaku Evidence Review
# Creatine Memory Meta-analysis: What the Evidence Says

## Quick Answer

Creatine Memory Meta-analysis has 2 source documents in the current Migaku evidence database. The strongest available sources in this first pass are systematic review, so conclusions should be framed as evidence-aware guidance rather than medical advice.

## Key Takeaways

- This page is generated only from sources stored in the Migaku evidence knowledge base.
- Current evidence mix: 1 systematic review, 1 preclinical study.
- Claims should be interpreted with the source type, study design, population, and publication date in mind.
- This article is educational and does not replace care from a qualified clinician.

## Evidence Map

| Source | Evidence type | Level | Date | Identifier |
| --- | --- | ---: | --- | --- |
| Commentary: The effects of creatine supplementation on cognitive function in adults: a systematic review and meta-analysis. | systematic review | 1 | 2026-04-10 | 10.3389/fnut.2026.1716285 |
| Assessing Cognitive Deterioration After COVID-19 Infection (The ACDC Study): An Exploratory Multimodal Neuroimaging Study | preclinical study | 4 | 2026-05-30 | 10.3390/jcm15114241 |

## What The Sources Report

- Commentary: The effects of creatine supplementation on cognitive function in adults: a systematic review and meta-analysis. [Citherlet T (2026); evidence level 1]
- A large study in the UK population, albeit based on subjective reporting, found persistent cognitive impairment equivalent to minus three IQ points on a global measure of cognition in subjects with mild COVID-19 infection. [McLaughlin Jonathan (2026); evidence level 4]
- This increased to minus six and minus nine points, respectively, in subjects with persistent COVID-19 symptoms and in those who had been admitted to ITU owing to infection. [McLaughlin Jonathan (2026); evidence level 4]

## How To Read This Evidence

Evidence level 1 generally reflects systematic reviews or meta-analyses. Level 2 includes randomized trials, guidelines, or public-health guidance. Level 3 usually reflects observational or narrative-review evidence. Level 4 is weaker or early-stage evidence. The level is a sorting aid, not a final quality grade.

## Practical Interpretation

There is at least one systematic-review style source in the current set, so it deserves more weight than single-study evidence. For creatine memory meta-analysis, the next editorial step is to add more targeted sources and separate strong findings from early or indirect evidence.

## Limits Of This First Pass

This is a small-batch MVP article. It uses the first ingested sources for this topic and should be expanded with more targeted searches, license review, and human editorial checks before being treated as a definitive review.

## References

- Citherlet T (2026). Commentary: The effects of creatine supplementation on cognitive function in adults: a systematic review and meta-analysis.. DOI: 10.3389/fnut.2026.1716285. PMCID: PMC13105953. PMID: 42039906. https://pmc.ncbi.nlm.nih.gov/articles/PMC13105953/
- McLaughlin Jonathan (2026). Assessing Cognitive Deterioration After COVID-19 Infection (The ACDC Study): An Exploratory Multimodal Neuroimaging Study. DOI: 10.3390/jcm15114241. PMCID: PMC13257671. PMID: 42279104. License: CC BY 4.0. https://pmc.ncbi.nlm.nih.gov/articles/PMC13257671/

## Safety Note

Health information can change, and individual risk depends on medical history, medications, pregnancy status, age, and diagnosis. Talk with a qualified clinician before changing treatment, supplement, or medication routines.