# Creatine Endurance Randomized Trial: What the Evidence Says
Canonical: https://www.migaku.app/guides/creatine-endurance-randomized-trial-evidence-review
Category: evidence-review
Summary: Creatine Endurance Randomized Trial has 2 source documents in the current Migaku evidence database. The strongest available sources in this first pass are sys
Last reviewed: 2026-08-13
Reviewed by: Migaku Evidence Review
# Creatine Endurance Randomized Trial: What the Evidence Says

## Quick Answer

Creatine Endurance Randomized Trial has 2 source documents in the current Migaku evidence database. The strongest available sources in this first pass are systematic review, so conclusions should be framed as evidence-aware guidance rather than medical advice.

## Key Takeaways

- This page is generated only from sources stored in the Migaku evidence knowledge base.
- Current evidence mix: 1 systematic review, 1 narrative review.
- Claims should be interpreted with the source type, study design, population, and publication date in mind.
- This article is educational and does not replace care from a qualified clinician.

## Evidence Map

| Source | Evidence type | Level | Date | Identifier |
| --- | --- | ---: | --- | --- |
| Comparative Effects of Dietary Protein, Creatine, and Omega-3 Supplementation on Muscle Strength, Endurance, and Recovery in Trained Athletes: A Systematic Review and Network Meta-Analysis | systematic review | 1 | 2026-03-13 | 10.3390/nu18060909 |
| Creatine Supplementation in Endurance and Mixed-Sport Contexts: A Scoping Review of Performance, Recovery, and Body Composition | narrative review | 3 | 2026-05-24 | 10.3390/nu18111677 |

## What The Sources Report

- Trained athletes, who are considered to be individuals following organized exercise programs for at least six months, can be considered a specific group with increased nutritional demands and specialized physiological responses to nutritional supplements. [Wang Ziyu (2026); evidence level 1]
- Although the current body of evidence is large, it is fraught with important limitations that impair its translational value for athletic populations. [Wang Ziyu (2026); evidence level 1]
- Emerging research suggests that creatine may also offer benefits beyond its classical scope through mechanisms including increased glycogen storage, muscle cell hydration, buffering intramuscular acidosis, and attenuation of muscle damage and inflammation. [Wesołowski Igor (2026); evidence level 3]
- Current evidence provides an incomplete and inconsistent picture of creatine's role in endurance and mixed sports. [Wesołowski Igor (2026); evidence level 3]

## How To Read This Evidence

Evidence level 1 generally reflects systematic reviews or meta-analyses. Level 2 includes randomized trials, guidelines, or public-health guidance. Level 3 usually reflects observational or narrative-review evidence. Level 4 is weaker or early-stage evidence. The level is a sorting aid, not a final quality grade.

## Practical Interpretation

There is at least one systematic-review style source in the current set, so it deserves more weight than single-study evidence. For creatine endurance randomized trial, the next editorial step is to add more targeted sources and separate strong findings from early or indirect evidence.

## Limits Of This First Pass

This is a small-batch MVP article. It uses the first ingested sources for this topic and should be expanded with more targeted searches, license review, and human editorial checks before being treated as a definitive review.

## References

- Wang Ziyu (2026). Comparative Effects of Dietary Protein, Creatine, and Omega-3 Supplementation on Muscle Strength, Endurance, and Recovery in Trained Athletes: A Systematic Review and Network Meta-Analysis. DOI: 10.3390/nu18060909. PMCID: PMC13029179. PMID: 41901084. License: CC BY 4.0. https://pmc.ncbi.nlm.nih.gov/articles/PMC13029179/
- Wesołowski Igor (2026). Creatine Supplementation in Endurance and Mixed-Sport Contexts: A Scoping Review of Performance, Recovery, and Body Composition. DOI: 10.3390/nu18111677. PMCID: PMC13258674. PMID: 42280321. License: CC BY 4.0. https://pmc.ncbi.nlm.nih.gov/articles/PMC13258674/

## Safety Note

Health information can change, and individual risk depends on medical history, medications, pregnancy status, age, and diagnosis. Talk with a qualified clinician before changing treatment, supplement, or medication routines.