# Citrulline Exercise Performance Meta-analysis: What the Evidence Says
Canonical: https://www.migaku.app/guides/citrulline-exercise-performance-meta-analysis-evidence-review
Category: evidence-review
Summary: Citrulline Exercise Performance Meta-analysis has 2 source documents in the current Migaku evidence database. The strongest available sources in this first pa
Last reviewed: 2026-06-08
Reviewed by: Migaku Evidence Review
# Citrulline Exercise Performance Meta-analysis: What the Evidence Says

## Quick Answer

Citrulline Exercise Performance Meta-analysis has 2 source documents in the current Migaku evidence database. The strongest available sources in this first pass are randomized trial, so conclusions should be framed as evidence-aware guidance rather than medical advice.

## Key Takeaways

- This page is generated only from sources stored in the Migaku evidence knowledge base.
- Current evidence mix: 1 randomized trial, 1 research article.
- Claims should be interpreted with the source type, study design, population, and publication date in mind.
- This article is educational and does not replace care from a qualified clinician.

## Evidence Map

| Source | Evidence type | Level | Date | Identifier |
| --- | --- | ---: | --- | --- |
| Effects of Acute Citrulline Malate Supplementation on Repeated 100 m Sprint Performance in Trained Sprinters: A Randomized Crossover Study | randomized trial | 2 | 2026-04-07 | 10.3390/sports14040143 |
| Acute effects of citrulline malate and L-arginine, alone and in combination, on anaerobic performance indicators in highly trained taekwondo athletes | research article | 4 | 2026-03-25 | 10.3389/fnut.2026.1788549 |

## What The Sources Report

- For example, citrulline supplementation has been reported to improve cycling time-trial performance and oxygen uptake kinetics, while acute CM ingestion has also been associated with improved resistance exercise performance and reduced ratings of perceived exertion (RPE). [Yamanaka Ryo (2026); evidence level 2]
- For example, creatine-based supplementation has improved repeated sprint performance in some treadmill- and field-based protocols, whereas interventions targeting related nitric oxide pathways do not necessarily enhance anaerobic performance in trained athletes. [Yamanaka Ryo (2026); evidence level 2]
- Through its involvement in NO-related pathways, L-ARG supplementation has been associated with changes in vascular function and blood flow, which may influence exercise-related physiological responses (,-). [Uçar Halil (2026); evidence level 4]
- However, the findings across these studies remain inconsistent, and conclusive evidence supporting clear performance or recovery benefits has yet to be established. [Uçar Halil (2026); evidence level 4]

## How To Read This Evidence

Evidence level 1 generally reflects systematic reviews or meta-analyses. Level 2 includes randomized trials, guidelines, or public-health guidance. Level 3 usually reflects observational or narrative-review evidence. Level 4 is weaker or early-stage evidence. The level is a sorting aid, not a final quality grade.

## Practical Interpretation

There is trial evidence in the current set, but population and intervention details still matter. For citrulline exercise performance meta-analysis, the next editorial step is to add more targeted sources and separate strong findings from early or indirect evidence.

## Limits Of This First Pass

This is a small-batch MVP article. It uses the first ingested sources for this topic and should be expanded with more targeted searches, license review, and human editorial checks before being treated as a definitive review.

## References

- Yamanaka Ryo (2026). Effects of Acute Citrulline Malate Supplementation on Repeated 100 m Sprint Performance in Trained Sprinters: A Randomized Crossover Study. DOI: 10.3390/sports14040143. PMCID: PMC13120297. PMID: 42043075. License: CC BY 4.0. https://pmc.ncbi.nlm.nih.gov/articles/PMC13120297/
- Uçar Halil (2026). Acute effects of citrulline malate and L-arginine, alone and in combination, on anaerobic performance indicators in highly trained taekwondo athletes. DOI: 10.3389/fnut.2026.1788549. PMCID: PMC13057471. PMID: 41958907. License: CC BY 4.0. https://pmc.ncbi.nlm.nih.gov/articles/PMC13057471/

## Safety Note

Health information can change, and individual risk depends on medical history, medications, pregnancy status, age, and diagnosis. Talk with a qualified clinician before changing treatment, supplement, or medication routines.