# Citrulline Endurance Performance Meta-analysis: What the Evidence Says
Canonical: https://www.migaku.app/guides/citrulline-endurance-performance-meta-analysis-evidence-review
Category: evidence-review
Summary: Citrulline Endurance Performance Meta-analysis has 2 source documents in the current Migaku evidence database. The strongest available sources in this first p
Last reviewed: 2026-05-26
Reviewed by: Migaku Evidence Review
# Citrulline Endurance Performance Meta-analysis: What the Evidence Says

## Quick Answer

Citrulline Endurance Performance Meta-analysis has 2 source documents in the current Migaku evidence database. The strongest available sources in this first pass are mixed biomedical and public-health sources, so conclusions should be framed as evidence-aware guidance rather than medical advice.

## Key Takeaways

- This page is generated only from sources stored in the Migaku evidence knowledge base.
- Current evidence mix: 1 research article, 1 preclinical study.
- Claims should be interpreted with the source type, study design, population, and publication date in mind.
- This article is educational and does not replace care from a qualified clinician.

## Evidence Map

| Source | Evidence type | Level | Date | Identifier |
| --- | --- | ---: | --- | --- |
| Acute effects of citrulline malate and L-arginine, alone and in combination, on anaerobic performance indicators in highly trained taekwondo athletes | research article | 4 | 2026-03-25 | 10.3389/fnut.2026.1788549 |
| Synergistic Actions of Natural Compounds for Enhancing Cognitive and Physical Performance: A Narrative Review | preclinical study | 4 | 2026-01-30 | 10.7759/cureus.102674 |

## What The Sources Report

- Through its involvement in NO-related pathways, L-ARG supplementation has been associated with changes in vascular function and blood flow, which may influence exercise-related physiological responses (,-). [Uçar Halil (2026); evidence level 4]
- However, the findings across these studies remain inconsistent, and conclusive evidence supporting clear performance or recovery benefits has yet to be established. [Uçar Halil (2026); evidence level 4]
- Energy drink consumption has grown exponentially across adolescents, young adults, athletes, and shift workers, driven by demands for prolonged alertness and improved performance . [Muacevic Alexander (2026); evidence level 4]
- Because of heterogeneity in study designs, populations, dosing regimens, and outcome measures, no formal risk-of-bias tool or quantitative meta-analysis was applied. [Muacevic Alexander (2026); evidence level 4]

## How To Read This Evidence

Evidence level 1 generally reflects systematic reviews or meta-analyses. Level 2 includes randomized trials, guidelines, or public-health guidance. Level 3 usually reflects observational or narrative-review evidence. Level 4 is weaker or early-stage evidence. The level is a sorting aid, not a final quality grade.

## Practical Interpretation

For citrulline endurance performance meta-analysis, the current source set is useful for orientation, but it is not yet broad enough for strong claims. Use cautious language and keep conclusions close to the cited sources.

## Limits Of This First Pass

This is a small-batch MVP article. It uses the first ingested sources for this topic and should be expanded with more targeted searches, license review, and human editorial checks before being treated as a definitive review.

## References

- Uçar Halil (2026). Acute effects of citrulline malate and L-arginine, alone and in combination, on anaerobic performance indicators in highly trained taekwondo athletes. DOI: 10.3389/fnut.2026.1788549. PMCID: PMC13057471. PMID: 41958907. License: CC BY 4.0. https://pmc.ncbi.nlm.nih.gov/articles/PMC13057471/
- Muacevic Alexander (2026). Synergistic Actions of Natural Compounds for Enhancing Cognitive and Physical Performance: A Narrative Review. DOI: 10.7759/cureus.102674. PMCID: PMC12950988. PMID: 41777984. License: CC BY 4.0. https://pmc.ncbi.nlm.nih.gov/articles/PMC12950988/

## Safety Note

Health information can change, and individual risk depends on medical history, medications, pregnancy status, age, and diagnosis. Talk with a qualified clinician before changing treatment, supplement, or medication routines.