# Citrulline Blood Pressure Meta-analysis: What the Evidence Says
Canonical: https://www.migaku.app/guides/citrulline-blood-pressure-meta-analysis-evidence-review
Category: evidence-review
Summary: Citrulline Blood Pressure Meta-analysis has 2 source documents in the current Migaku evidence database. The strongest available sources in this first pass are
Last reviewed: 2026-06-28
Reviewed by: Migaku Evidence Review
# Citrulline Blood Pressure Meta-analysis: What the Evidence Says

## Quick Answer

Citrulline Blood Pressure Meta-analysis has 2 source documents in the current Migaku evidence database. The strongest available sources in this first pass are systematic review, so conclusions should be framed as evidence-aware guidance rather than medical advice.

## Key Takeaways

- This page is generated only from sources stored in the Migaku evidence knowledge base.
- Current evidence mix: 1 systematic review, 1 research article.
- Claims should be interpreted with the source type, study design, population, and publication date in mind.
- This article is educational and does not replace care from a qualified clinician.

## Evidence Map

| Source | Evidence type | Level | Date | Identifier |
| --- | --- | ---: | --- | --- |
| Effect of L‐Citrulline Intake on Blood Pressure in Cold Environments: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials | systematic review | 1 | 2026-03-06 | 10.1002/fsn3.71603 |
| Liposomal encapsulation of L-arginine and L-citrulline enhances pharmacokinetics and therapeutic effects in a model of preeclampsia and fetal growth restriction | research article | 4 | 2026-03-18 | 10.1038/s41598-026-43958-y |

## What The Sources Report

- More importantly, this BP elevation was closely associated with adverse outcomes, with cardiovascular mortality risk increasing by 21% for every 10 mmHg increase in SBP, and winter cardiovascular mortality rates being 41% higher than those in summer (Yang et al. ). [Luo Ping (2026); evidence level 1]
- Given that cold environment-induced BP elevation is one of the important modifiable risk factors for CVD (Gu et al. ; Yokoyama et al. ), targeted interventions to control elevated BP during cold weather are particularly crucial (Xu et al. ,). [Luo Ping (2026); evidence level 1]
- Due to the complex and multifactorial nature of these pregnancy-related complications and the potential risk of any intervention on the developing fetus to date, no effective therapeutic approaches for prevention or treatment exist, besides supportive treatments aspirin, antihypertensives, magnesium sulfate and timely delivery. [van Kammen Caren (2026); evidence level 4]
- Reduced nitric oxide (NO) bioavailability plays a key role in maintaining vascular function and placental health. [van Kammen Caren (2026); evidence level 4]

## How To Read This Evidence

Evidence level 1 generally reflects systematic reviews or meta-analyses. Level 2 includes randomized trials, guidelines, or public-health guidance. Level 3 usually reflects observational or narrative-review evidence. Level 4 is weaker or early-stage evidence. The level is a sorting aid, not a final quality grade.

## Practical Interpretation

There is at least one systematic-review style source in the current set, so it deserves more weight than single-study evidence. For citrulline blood pressure meta-analysis, the next editorial step is to add more targeted sources and separate strong findings from early or indirect evidence.

## Limits Of This First Pass

This is a small-batch MVP article. It uses the first ingested sources for this topic and should be expanded with more targeted searches, license review, and human editorial checks before being treated as a definitive review.

## References

- Luo Ping (2026). Effect of L‐Citrulline Intake on Blood Pressure in Cold Environments: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials. DOI: 10.1002/fsn3.71603. PMCID: PMC12965904. PMID: 41797970. License: CC BY 4.0. https://pmc.ncbi.nlm.nih.gov/articles/PMC12965904/
- van Kammen Caren (2026). Liposomal encapsulation of L-arginine and L-citrulline enhances pharmacokinetics and therapeutic effects in a model of preeclampsia and fetal growth restriction. DOI: 10.1038/s41598-026-43958-y. PMCID: PMC13133094. PMID: 41844935. License: https://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ This article is .... https://pmc.ncbi.nlm.nih.gov/articles/PMC13133094/

## Safety Note

Health information can change, and individual risk depends on medical history, medications, pregnancy status, age, and diagnosis. Talk with a qualified clinician before changing treatment, supplement, or medication routines.