# Calcium Supplementation Bone Density Meta-analysis: What the Evidence Says
Canonical: https://www.migaku.app/guides/calcium-supplementation-bone-density-meta-analysis-evidence-review
Category: evidence-review
Summary: Calcium Supplementation Bone Density Meta-analysis has 2 source documents in the current Migaku evidence database. The strongest available sources in this fir
Last reviewed: 2026-07-05
Reviewed by: Migaku Evidence Review
# Calcium Supplementation Bone Density Meta-analysis: What the Evidence Says

## Quick Answer

Calcium Supplementation Bone Density Meta-analysis has 2 source documents in the current Migaku evidence database. The strongest available sources in this first pass are systematic review, so conclusions should be framed as evidence-aware guidance rather than medical advice.

## Key Takeaways

- This page is generated only from sources stored in the Migaku evidence knowledge base.
- Current evidence mix: 2 systematic review.
- Claims should be interpreted with the source type, study design, population, and publication date in mind.
- This article is educational and does not replace care from a qualified clinician.

## Evidence Map

| Source | Evidence type | Level | Date | Identifier |
| --- | --- | ---: | --- | --- |
| Calcium, vitamin D, or combined supplementation to prevent fractures and falls: systematic review and meta-analysis | systematic review | 1 | 2026-01-01 | 10.1136/bmj-2025-088050 |
| Effects of Prunes on Bone Density in Humans: A Systematic Review and Meta-Analysis of Randomized Controlled Trials | systematic review | 1 | 2026-04-23 | 10.3390/nu18091338 |

## What The Sources Report

- Secondary outcomes included the risk of hip fracture, non-vertebral fracture, vertebral fracture, and falling, as well as the total number of falls. [Massé Olivier (2026); evidence level 1]
- If unpublished data, not obtained through personal communications, were found in another systematic review, we used that review to complete data extraction. [Massé Olivier (2026); evidence level 1]
- Osteoporosis, the primary risk factor for fragility fractures, is highly prevalent and projected to increase as populations age globally. [Treister-Goltzman Yulia (2026); evidence level 1]
- Fragility fractures, particularly of the hip, spine, and wrist, are associated with substantial morbidity, loss of independence, increased mortality, and considerable healthcare costs, making osteoporosis a significant public health concern. [Treister-Goltzman Yulia (2026); evidence level 1]

## How To Read This Evidence

Evidence level 1 generally reflects systematic reviews or meta-analyses. Level 2 includes randomized trials, guidelines, or public-health guidance. Level 3 usually reflects observational or narrative-review evidence. Level 4 is weaker or early-stage evidence. The level is a sorting aid, not a final quality grade.

## Practical Interpretation

There is at least one systematic-review style source in the current set, so it deserves more weight than single-study evidence. For calcium supplementation bone density meta-analysis, the next editorial step is to add more targeted sources and separate strong findings from early or indirect evidence.

## Limits Of This First Pass

This is a small-batch MVP article. It uses the first ingested sources for this topic and should be expanded with more targeted searches, license review, and human editorial checks before being treated as a definitive review.

## References

- Massé Olivier (2026). Calcium, vitamin D, or combined supplementation to prevent fractures and falls: systematic review and meta-analysis. DOI: 10.1136/bmj-2025-088050. PMCID: PMC13188451. PMID: 42161415. License: CC BY 4.0. https://pmc.ncbi.nlm.nih.gov/articles/PMC13188451/
- Treister-Goltzman Yulia (2026). Effects of Prunes on Bone Density in Humans: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. DOI: 10.3390/nu18091338. PMCID: PMC13164729. PMID: 42123941. License: CC BY 4.0. https://pmc.ncbi.nlm.nih.gov/articles/PMC13164729/

## Safety Note

Health information can change, and individual risk depends on medical history, medications, pregnancy status, age, and diagnosis. Talk with a qualified clinician before changing treatment, supplement, or medication routines.