# Calcium Kidney Stones Meta-analysis: What the Evidence Says
Canonical: https://www.migaku.app/guides/calcium-kidney-stones-meta-analysis-evidence-review
Category: evidence-review
Summary: Calcium Kidney Stones Meta-analysis has 2 source documents in the current Migaku evidence database. The strongest available sources in this first pass are sys
Last reviewed: 2026-06-01
Reviewed by: Migaku Evidence Review
# Calcium Kidney Stones Meta-analysis: What the Evidence Says

## Quick Answer

Calcium Kidney Stones Meta-analysis has 2 source documents in the current Migaku evidence database. The strongest available sources in this first pass are systematic review, so conclusions should be framed as evidence-aware guidance rather than medical advice.

## Key Takeaways

- This page is generated only from sources stored in the Migaku evidence knowledge base.
- Current evidence mix: 1 systematic review, 1 narrative review.
- Claims should be interpreted with the source type, study design, population, and publication date in mind.
- This article is educational and does not replace care from a qualified clinician.

## Evidence Map

| Source | Evidence type | Level | Date | Identifier |
| --- | --- | ---: | --- | --- |
| Effect of parathyroidectomy versus non-surgical management on renal outcomes in primary hyperparathyroidism: protocol for a systematic review and meta-analysis | systematic review | 1 | 2026-01-01 | 10.1136/bmjopen-2025-115297 |
| The gut–kidney microbiome–oxalate axis in calcium oxalate nephrolithiasis: mechanisms and microbiome-based interventions | narrative review | 3 | 2026-04-15 | 10.3389/fcimb.2026.1804800 |

## What The Sources Report

- In a recent systematic review and meta-analysis of 53 studies (n=40 310), male sex and elevated urinary calcium were identified as the strongest and highest-certainty risk factors for renal stones in PHPT.These findings highlight hypercalciuria as a central biochemical driver of renal risk and suggest that surgical correction should, in theory, reduce stone formation and preserve renal function. [Jay Mohammad (2026); evidence level 1]
- Singh Ospinaand Anagnostisfound no convincing reduction in renal stone risk or improvement in renal function with parathyroidectomy. [Jay Mohammad (2026); evidence level 1]
- However, the precise mechanisms linking these risk factors to stone formation remain incompletely understood. [Pang Shuo (2026); evidence level 3]

## How To Read This Evidence

Evidence level 1 generally reflects systematic reviews or meta-analyses. Level 2 includes randomized trials, guidelines, or public-health guidance. Level 3 usually reflects observational or narrative-review evidence. Level 4 is weaker or early-stage evidence. The level is a sorting aid, not a final quality grade.

## Practical Interpretation

There is at least one systematic-review style source in the current set, so it deserves more weight than single-study evidence. For calcium kidney stones meta-analysis, the next editorial step is to add more targeted sources and separate strong findings from early or indirect evidence.

## Limits Of This First Pass

This is a small-batch MVP article. It uses the first ingested sources for this topic and should be expanded with more targeted searches, license review, and human editorial checks before being treated as a definitive review.

## References

- Jay Mohammad (2026). Effect of parathyroidectomy versus non-surgical management on renal outcomes in primary hyperparathyroidism: protocol for a systematic review and meta-analysis. DOI: 10.1136/bmjopen-2025-115297. PMCID: PMC13182485. PMID: 42129979. License: CC BY 4.0. https://pmc.ncbi.nlm.nih.gov/articles/PMC13182485/
- Pang Shuo (2026). The gut–kidney microbiome–oxalate axis in calcium oxalate nephrolithiasis: mechanisms and microbiome-based interventions. DOI: 10.3389/fcimb.2026.1804800. PMCID: PMC13124710. PMID: 42064216. License: CC BY 4.0. https://pmc.ncbi.nlm.nih.gov/articles/PMC13124710/

## Safety Note

Health information can change, and individual risk depends on medical history, medications, pregnancy status, age, and diagnosis. Talk with a qualified clinician before changing treatment, supplement, or medication routines.