# Caffeine Exercise Performance Randomized Trial: What the Evidence Says Canonical: https://www.migaku.app/guides/caffeine-exercise-performance-randomized-trial-evidence-review Category: evidence-review Summary: Caffeine Exercise Performance Randomized Trial has 2 source documents in the current Migaku evidence database. The strongest available sources in this first p Last reviewed: 2026-06-16 Reviewed by: Migaku Evidence Review # Caffeine Exercise Performance Randomized Trial: What the Evidence Says ## Quick Answer Caffeine Exercise Performance Randomized Trial has 2 source documents in the current Migaku evidence database. The strongest available sources in this first pass are mixed biomedical and public-health sources, so conclusions should be framed as evidence-aware guidance rather than medical advice. ## Key Takeaways - This page is generated only from sources stored in the Migaku evidence knowledge base. - Current evidence mix: 2 research article. - Claims should be interpreted with the source type, study design, population, and publication date in mind. - This article is educational and does not replace care from a qualified clinician. ## Evidence Map | Source | Evidence type | Level | Date | Identifier | | --- | --- | ---: | --- | --- | | The Effect of CYP1A2 Gene Polymorphisms on Caffeine Pharmacokinetics and Exercise Performance in Male Recreational Athletes | research article | 4 | 2026-06-02 | 10.1002/ejsc.70203 | | An extract from whole Coffea arabica coffee cherry improves time trial performance, but not muscle glycogen resynthesis, in trained cyclists | research article | 4 | 2026-06-03 | 10.1080/15502783.2026.2682323 | ## What The Sources Report - Caffeine's appeal has increased due to the perceptual, cognitive and physiological effects it can exert such as reducing fatigue and perceived exertion and improving mood and cognition (Ágoston et al. ; Barcelos et al. ; Barreto et al. ). [Masters Chloe (2026); evidence level 4] - In a recent systematic review, 4 of 17 studies found the AA allele polymorphism influenced the ergogenic effects of caffeine, with improvement in exercise performance in these athletes compared to athletes with AC or CC genotypes (Grgic et al. ). [Masters Chloe (2026); evidence level 4] - All participants met the classification of being Tier 2 athletes, and habitual caffeine use was chosen to minimize the risk of adverse events from unaccustomed caffeine intake. [Pavis George F. (2026); evidence level 4] - From baseline, plasma caffeine concentration remained unchanged with PLA throughout SS, but was elevated by CB immediately prior to, and at 10, 20 and 30 mins of SS (interaction < 0.001; all timepoints increased from baseline, and greater than PLA; post hoc < 0.001). [Pavis George F. (2026); evidence level 4] ## How To Read This Evidence Evidence level 1 generally reflects systematic reviews or meta-analyses. Level 2 includes randomized trials, guidelines, or public-health guidance. Level 3 usually reflects observational or narrative-review evidence. Level 4 is weaker or early-stage evidence. The level is a sorting aid, not a final quality grade. ## Practical Interpretation For caffeine exercise performance randomized trial, the current source set is useful for orientation, but it is not yet broad enough for strong claims. Use cautious language and keep conclusions close to the cited sources. ## Limits Of This First Pass This is a small-batch MVP article. It uses the first ingested sources for this topic and should be expanded with more targeted searches, license review, and human editorial checks before being treated as a definitive review. ## References - Masters Chloe (2026). The Effect of CYP1A2 Gene Polymorphisms on Caffeine Pharmacokinetics and Exercise Performance in Male Recreational Athletes. DOI: 10.1002/ejsc.70203. PMCID: PMC13239719. PMID: 42230302. License: https://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open .... https://pmc.ncbi.nlm.nih.gov/articles/PMC13239719/ - Pavis George F. (2026). An extract from whole Coffea arabica coffee cherry improves time trial performance, but not muscle glycogen resynthesis, in trained cyclists. DOI: 10.1080/15502783.2026.2682323. PMCID: PMC13235231. PMID: 42234539. License: CC BY 4.0. https://pmc.ncbi.nlm.nih.gov/articles/PMC13235231/ ## Safety Note Health information can change, and individual risk depends on medical history, medications, pregnancy status, age, and diagnosis. Talk with a qualified clinician before changing treatment, supplement, or medication routines.