# Caffeine Exercise Performance Meta-analysis: What the Evidence Says
Canonical: https://www.migaku.app/guides/caffeine-exercise-performance-meta-analysis-evidence-review
Category: evidence-review
Summary: Caffeine Exercise Performance Meta-analysis has 2 source documents in the current Migaku evidence database. The strongest available sources in this first pass
Last reviewed: 2026-06-28
Reviewed by: Migaku Evidence Review
# Caffeine Exercise Performance Meta-analysis: What the Evidence Says

## Quick Answer

Caffeine Exercise Performance Meta-analysis has 2 source documents in the current Migaku evidence database. The strongest available sources in this first pass are systematic review, so conclusions should be framed as evidence-aware guidance rather than medical advice.

## Key Takeaways

- This page is generated only from sources stored in the Migaku evidence knowledge base.
- Current evidence mix: 1 systematic review, 1 research article.
- Claims should be interpreted with the source type, study design, population, and publication date in mind.
- This article is educational and does not replace care from a qualified clinician.

## Evidence Map

| Source | Evidence type | Level | Date | Identifier |
| --- | --- | ---: | --- | --- |
| Caffeine makes a splash: a systematic review and multilevel meta-analysis exploring the effects of caffeine intake on swimming performance | systematic review | 1 | 2026-06-21 | 10.1080/15502783.2026.2692016 |
| The Effect of CYP1A2 Gene Polymorphisms on Caffeine Pharmacokinetics and Exercise Performance in Male Recreational Athletes | research article | 4 | 2026-06-02 | 10.1002/ejsc.70203 |

## What The Sources Report

- Consistent with these findings, in-competition urine monitoring data show that median urinary caffeine concentration in aquatics increased from 0.1 µg/mL in 2004 to 0.7 µg/mL in 2015, suggesting an increase in caffeine use. [Wang Ziyu (2026); evidence level 1]
- Available evidence supports caffeine's ergogenic effects in various sports disciplines and competitive scenarios. [Wang Ziyu (2026); evidence level 1]
- Caffeine's appeal has increased due to the perceptual, cognitive and physiological effects it can exert such as reducing fatigue and perceived exertion and improving mood and cognition (Ágoston et al. ; Barcelos et al. ; Barreto et al. ). [Masters Chloe (2026); evidence level 4]
- In a recent systematic review, 4 of 17 studies found the AA allele polymorphism influenced the ergogenic effects of caffeine, with improvement in exercise performance in these athletes compared to athletes with AC or CC genotypes (Grgic et al. ). [Masters Chloe (2026); evidence level 4]

## How To Read This Evidence

Evidence level 1 generally reflects systematic reviews or meta-analyses. Level 2 includes randomized trials, guidelines, or public-health guidance. Level 3 usually reflects observational or narrative-review evidence. Level 4 is weaker or early-stage evidence. The level is a sorting aid, not a final quality grade.

## Practical Interpretation

There is at least one systematic-review style source in the current set, so it deserves more weight than single-study evidence. For caffeine exercise performance meta-analysis, the next editorial step is to add more targeted sources and separate strong findings from early or indirect evidence.

## Limits Of This First Pass

This is a small-batch MVP article. It uses the first ingested sources for this topic and should be expanded with more targeted searches, license review, and human editorial checks before being treated as a definitive review.

## References

- Wang Ziyu (2026). Caffeine makes a splash: a systematic review and multilevel meta-analysis exploring the effects of caffeine intake on swimming performance. DOI: 10.1080/15502783.2026.2692016. PMCID: PMC13288720. PMID: 42323844. License: CC BY 4.0. https://pmc.ncbi.nlm.nih.gov/articles/PMC13288720/
- Masters Chloe (2026). The Effect of CYP1A2 Gene Polymorphisms on Caffeine Pharmacokinetics and Exercise Performance in Male Recreational Athletes. DOI: 10.1002/ejsc.70203. PMCID: PMC13239719. PMID: 42230302. License: https://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open .... https://pmc.ncbi.nlm.nih.gov/articles/PMC13239719/

## Safety Note

Health information can change, and individual risk depends on medical history, medications, pregnancy status, age, and diagnosis. Talk with a qualified clinician before changing treatment, supplement, or medication routines.