# Cacao Flavanol Anxiety Randomized Trial: What the Evidence Says
Canonical: https://www.migaku.app/guides/cacao-flavanol-anxiety-randomized-trial-evidence-review
Category: evidence-review
Summary: Cacao Flavanol Anxiety Randomized Trial has 2 source documents in the current Migaku evidence database. The strongest available sources in this first pass are
Last reviewed: 2026-08-09
Reviewed by: Migaku Evidence Review
# Cacao Flavanol Anxiety Randomized Trial: What the Evidence Says

## Quick Answer

Cacao Flavanol Anxiety Randomized Trial has 2 source documents in the current Migaku evidence database. The strongest available sources in this first pass are randomized trial, so conclusions should be framed as evidence-aware guidance rather than medical advice.

## Key Takeaways

- This page is generated only from sources stored in the Migaku evidence knowledge base.
- Current evidence mix: 2 randomized trial.
- Claims should be interpreted with the source type, study design, population, and publication date in mind.
- This article is educational and does not replace care from a qualified clinician.

## Evidence Map

| Source | Evidence type | Level | Date | Identifier |
| --- | --- | ---: | --- | --- |
| Effects of Cacao Flavonoids in Long COVID-19 Patients with Chronic Fatigue: FLALOC, a Placebo-Controlled Randomized Clinical Trial | randomized trial | 2 | 2026-02-13 | 10.3390/jcm15041468 |
| Effect of Cocoa Supplementation on the Biochemical and Clinical Profile and the Somatosensory Processing of Diabetic Peripheral and Autonomic Neuropathy: A Randomized Clinical Trial | randomized trial | 2 | 2025-08-20 | 10.3390/ijms26168033 |

## What The Sources Report

- It includes increased interferons, tumor necrosis factor, bradykinin, serine proteases, and soluble thrombomodulin, and altered clot lysis times, all of which contribute to microvascular and thrombotic disease. [Munguía Levy (2026); evidence level 2]
- A myriad of causes can trigger fatigue, but its development has been strongly associated with post-viral phases of infection. [Munguía Levy (2026); evidence level 2]
- Some factors that increase the possibility of developing DN are the duration of diabetes, high glycated hemoglobin (HbA1c) values, smoking, obesity, high blood pressure, and dyslipidemia, all of which are metabolic risk factors and are associated with persistent inflammation and oxidative stress. [Kababie-Ameo Rebeca (2025); evidence level 2]
- The Hoffman reflex (hereafter referred to as the H-reflex) is produced by an electrical pulse applied to a peripheral nerve and is recorded in a specific muscle, allowing for an evaluation of the nerve fibers and associated neural circuits under both normal and pathological conditions. [Kababie-Ameo Rebeca (2025); evidence level 2]

## How To Read This Evidence

Evidence level 1 generally reflects systematic reviews or meta-analyses. Level 2 includes randomized trials, guidelines, or public-health guidance. Level 3 usually reflects observational or narrative-review evidence. Level 4 is weaker or early-stage evidence. The level is a sorting aid, not a final quality grade.

## Practical Interpretation

There is trial evidence in the current set, but population and intervention details still matter. For cacao flavanol anxiety randomized trial, the next editorial step is to add more targeted sources and separate strong findings from early or indirect evidence.

## Limits Of This First Pass

This is a small-batch MVP article. It uses the first ingested sources for this topic and should be expanded with more targeted searches, license review, and human editorial checks before being treated as a definitive review.

## References

- Munguía Levy (2026). Effects of Cacao Flavonoids in Long COVID-19 Patients with Chronic Fatigue: FLALOC, a Placebo-Controlled Randomized Clinical Trial. DOI: 10.3390/jcm15041468. PMCID: PMC12941747. PMID: 41753154. License: CC BY 4.0. https://pmc.ncbi.nlm.nih.gov/articles/PMC12941747/
- Kababie-Ameo Rebeca (2025). Effect of Cocoa Supplementation on the Biochemical and Clinical Profile and the Somatosensory Processing of Diabetic Peripheral and Autonomic Neuropathy: A Randomized Clinical Trial. DOI: 10.3390/ijms26168033. PMCID: PMC12386359. PMID: 40869354. License: CC BY 4.0. https://pmc.ncbi.nlm.nih.gov/articles/PMC12386359/

## Safety Note

Health information can change, and individual risk depends on medical history, medications, pregnancy status, age, and diagnosis. Talk with a qualified clinician before changing treatment, supplement, or medication routines.