# Ashwagandha Cortisol Randomized Trial: What the Evidence Says
Canonical: https://www.migaku.app/guides/ashwagandha-cortisol-randomized-trial-evidence-review
Category: evidence-review
Summary: Ashwagandha Cortisol Randomized Trial has 2 source documents in the current Migaku evidence database. The strongest available sources in this first pass are r
Last reviewed: 2026-07-06
Reviewed by: Migaku Evidence Review
# Ashwagandha Cortisol Randomized Trial: What the Evidence Says

## Quick Answer

Ashwagandha Cortisol Randomized Trial has 2 source documents in the current Migaku evidence database. The strongest available sources in this first pass are randomized trial, so conclusions should be framed as evidence-aware guidance rather than medical advice.

## Key Takeaways

- This page is generated only from sources stored in the Migaku evidence knowledge base.
- Current evidence mix: 1 randomized trial, 1 preclinical study.
- Claims should be interpreted with the source type, study design, population, and publication date in mind.
- This article is educational and does not replace care from a qualified clinician.

## Evidence Map

| Source | Evidence type | Level | Date | Identifier |
| --- | --- | ---: | --- | --- |
| Efficacy and safety of Ashwagandha root extract sustained-release (AshwaSR) capsules in healthy adult, stressed subjects: A randomized, double-blind, placebo-controlled, parallel-group, 3-arm clinical trial | randomized trial | 2 | 2026-03-13 | 10.1097/MD.0000000000047990 |
| Withania somnifera in Women’s Hormonal Modulation: A Narrative Review With Implications for Polycystic Ovary Syndrome and Premenstrual Syndrome | preclinical study | 4 | 2026-01-13 | 10.7759/cureus.101431 |

## What The Sources Report

- There is a paucity of evidence assessing the efficacy and safety of low-dose formulations of Ashwagandha in stress management. [Thanawala Shefali (2026); evidence level 2]
- We evaluated the efficacy and safety of AshwaSR capsules at doses of 150 and 300 mg in reducing stress and associated symptoms in healthy adults experiencing stress, over a period of 60 days of administration. [Thanawala Shefali (2026); evidence level 2]
- Despite established treatment protocols, conventional therapies are often associated with adverse side effects and may be insufficient in fully alleviating the symptoms of these conditions. [Muacevic Alexander (2026); evidence level 4]
- However, they may cause headaches, nausea, and breast tenderness, and increase the risk of venous thromboembolism. [Muacevic Alexander (2026); evidence level 4]

## How To Read This Evidence

Evidence level 1 generally reflects systematic reviews or meta-analyses. Level 2 includes randomized trials, guidelines, or public-health guidance. Level 3 usually reflects observational or narrative-review evidence. Level 4 is weaker or early-stage evidence. The level is a sorting aid, not a final quality grade.

## Practical Interpretation

There is trial evidence in the current set, but population and intervention details still matter. For ashwagandha cortisol randomized trial, the next editorial step is to add more targeted sources and separate strong findings from early or indirect evidence.

## Limits Of This First Pass

This is a small-batch MVP article. It uses the first ingested sources for this topic and should be expanded with more targeted searches, license review, and human editorial checks before being treated as a definitive review.

## References

- Thanawala Shefali (2026). Efficacy and safety of Ashwagandha root extract sustained-release (AshwaSR) capsules in healthy adult, stressed subjects: A randomized, double-blind, placebo-controlled, parallel-group, 3-arm clinical trial. DOI: 10.1097/MD.0000000000047990. PMCID: PMC12991725. PMID: 41824889. License: CC BY 4.0. https://pmc.ncbi.nlm.nih.gov/articles/PMC12991725/
- Muacevic Alexander (2026). Withania somnifera in Women’s Hormonal Modulation: A Narrative Review With Implications for Polycystic Ovary Syndrome and Premenstrual Syndrome. DOI: 10.7759/cureus.101431. PMCID: PMC12895992. PMID: 41694897. License: CC BY 4.0. https://pmc.ncbi.nlm.nih.gov/articles/PMC12895992/

## Safety Note

Health information can change, and individual risk depends on medical history, medications, pregnancy status, age, and diagnosis. Talk with a qualified clinician before changing treatment, supplement, or medication routines.